The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease.
Identifieur interne : 000014 ( Main/Exploration ); précédent : 000013; suivant : 000015The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease.
Auteurs : John M. Lee ; Pascal Derkinderen ; Jeffrey H. Kordower ; Roy Freeman ; David G. Munoz ; Thomas Kremer ; Wagner Zago ; Samantha J. Hutten ; Charles H. Adler ; Geidy E. Serrano ; Thomas G. BeachSource :
- Journal of neuropathology and experimental neurology [ 1554-6578 ] ; 2017.
Abstract
The neuropathological hallmark of Parkinson disease (PD) is abnormal accumulation of α-synuclein (α-syn). Demonstrating pathological α-syn in live patients would be useful for identifying and monitoring PD patients. To date, however, imaging and biofluid approaches have not permitted premortem assessment of pathological α-syn. α-syn pathology in the peripheral nervous system of patients with PD has been demonstrated in studies dating back more than 40 years. More recent work suggests that colon, submandibular gland and skin biopsies could be useful as expedient biomarkers but histological differentiation of pathological and normal peripheral α-syn has been challenging and multiple research groups have reported variable results. A variety of immunohistochemical methods have been employed but almost all studies to date originated at single centers with no independent, blinded replication. To address these issues, the Michael J. Fox Foundation for Parkinson's Research sponsored a series of meetings and investigations by several research groups with relevant experience. The major finding reported herein was that biopsies can be used to distinguish PD patients from normal subjects. However, full assessment of the clinical potential of biopsy will only be achieved through large, multicenter trials in which both the initial detection methodology and histology have been assessed by blinded panels of pathologists.
DOI: 10.1093/jnen/nlw103
PubMed: 28069931
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease.</title><author><name sortKey="Lee, John M" sort="Lee, John M" uniqKey="Lee J" first="John M" last="Lee">John M. Lee</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Freeman, Roy" sort="Freeman, Roy" uniqKey="Freeman R" first="Roy" last="Freeman">Roy Freeman</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Munoz, David G" sort="Munoz, David G" uniqKey="Munoz D" first="David G" last="Munoz">David G. Munoz</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Kremer, Thomas" sort="Kremer, Thomas" uniqKey="Kremer T" first="Thomas" last="Kremer">Thomas Kremer</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Zago, Wagner" sort="Zago, Wagner" uniqKey="Zago W" first="Wagner" last="Zago">Wagner Zago</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Hutten, Samantha J" sort="Hutten, Samantha J" uniqKey="Hutten S" first="Samantha J" last="Hutten">Samantha J. Hutten</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H" last="Adler">Charles H. Adler</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Serrano, Geidy E" sort="Serrano, Geidy E" uniqKey="Serrano G" first="Geidy E" last="Serrano">Geidy E. Serrano</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28069931</idno><idno type="pmid">28069931</idno><idno type="doi">10.1093/jnen/nlw103</idno><idno type="wicri:Area/PubMed/Corpus">000097</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000097</idno><idno type="wicri:Area/PubMed/Curation">000097</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000097</idno><idno type="wicri:Area/PubMed/Checkpoint">000097</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000097</idno><idno type="wicri:Area/Ncbi/Merge">002183</idno><idno type="wicri:Area/Ncbi/Curation">002183</idno><idno type="wicri:Area/Ncbi/Checkpoint">002183</idno><idno type="wicri:Area/Main/Merge">000014</idno><idno type="wicri:Area/Main/Curation">000014</idno><idno type="wicri:Area/Main/Exploration">000014</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The Search for a Peripheral Biopsy Indicator of α-Synuclein Pathology for Parkinson Disease.</title><author><name sortKey="Lee, John M" sort="Lee, John M" uniqKey="Lee J" first="John M" last="Lee">John M. Lee</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Freeman, Roy" sort="Freeman, Roy" uniqKey="Freeman R" first="Roy" last="Freeman">Roy Freeman</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Munoz, David G" sort="Munoz, David G" uniqKey="Munoz D" first="David G" last="Munoz">David G. Munoz</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Kremer, Thomas" sort="Kremer, Thomas" uniqKey="Kremer T" first="Thomas" last="Kremer">Thomas Kremer</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Zago, Wagner" sort="Zago, Wagner" uniqKey="Zago W" first="Wagner" last="Zago">Wagner Zago</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Hutten, Samantha J" sort="Hutten, Samantha J" uniqKey="Hutten S" first="Samantha J" last="Hutten">Samantha J. Hutten</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H" last="Adler">Charles H. Adler</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Serrano, Geidy E" sort="Serrano, Geidy E" uniqKey="Serrano G" first="Geidy E" last="Serrano">Geidy E. Serrano</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author><author><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name><affiliation><nlm:affiliation>From the Department of Pathology, NorthShore University Health System, University of Chicago, Pritzker School of Medicine, Evanston, Illinois (JML); Inserm, U913, Nantes F-44035; Nantes University, Nantes F-44035; Department of Neurology, CHU Nantes, Nantes F-44093, France (PD); Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, Illinois (JHK); Harvard Medical School; Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts (RF); Laboratory Medicine and Keenan Research Centre for Biomedical Research of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada (DGM); Roche Pharmaceutical Research and Early Development, Nord DTA, Biomarker and Clinical Imaging, Roche Innovation Center, F Hoffman-La Roche, Ltd., Basel, Switzerland (TK); Prothena Biosciences, Inc., South San Francisco, California (WZ); Michael J. Fox Foundation for Parkinson's Research, New York, New York (SJH); Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona (CHA); and Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, Arizona (GES, TGB).</nlm:affiliation><wicri:noCountry code="subField">TGB)</wicri:noCountry></affiliation></author></analytic><series><title level="j">Journal of neuropathology and experimental neurology</title><idno type="eISSN">1554-6578</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The neuropathological hallmark of Parkinson disease (PD) is abnormal accumulation of α-synuclein (α-syn). Demonstrating pathological α-syn in live patients would be useful for identifying and monitoring PD patients. To date, however, imaging and biofluid approaches have not permitted premortem assessment of pathological α-syn. α-syn pathology in the peripheral nervous system of patients with PD has been demonstrated in studies dating back more than 40 years. More recent work suggests that colon, submandibular gland and skin biopsies could be useful as expedient biomarkers but histological differentiation of pathological and normal peripheral α-syn has been challenging and multiple research groups have reported variable results. A variety of immunohistochemical methods have been employed but almost all studies to date originated at single centers with no independent, blinded replication. To address these issues, the Michael J. Fox Foundation for Parkinson's Research sponsored a series of meetings and investigations by several research groups with relevant experience. The major finding reported herein was that biopsies can be used to distinguish PD patients from normal subjects. However, full assessment of the clinical potential of biopsy will only be achieved through large, multicenter trials in which both the initial detection methodology and histology have been assessed by blinded panels of pathologists.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Adler, Charles H" sort="Adler, Charles H" uniqKey="Adler C" first="Charles H" last="Adler">Charles H. Adler</name><name sortKey="Beach, Thomas G" sort="Beach, Thomas G" uniqKey="Beach T" first="Thomas G" last="Beach">Thomas G. Beach</name><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name><name sortKey="Freeman, Roy" sort="Freeman, Roy" uniqKey="Freeman R" first="Roy" last="Freeman">Roy Freeman</name><name sortKey="Hutten, Samantha J" sort="Hutten, Samantha J" uniqKey="Hutten S" first="Samantha J" last="Hutten">Samantha J. Hutten</name><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name><name sortKey="Kremer, Thomas" sort="Kremer, Thomas" uniqKey="Kremer T" first="Thomas" last="Kremer">Thomas Kremer</name><name sortKey="Lee, John M" sort="Lee, John M" uniqKey="Lee J" first="John M" last="Lee">John M. Lee</name><name sortKey="Munoz, David G" sort="Munoz, David G" uniqKey="Munoz D" first="David G" last="Munoz">David G. Munoz</name><name sortKey="Serrano, Geidy E" sort="Serrano, Geidy E" uniqKey="Serrano G" first="Geidy E" last="Serrano">Geidy E. Serrano</name><name sortKey="Zago, Wagner" sort="Zago, Wagner" uniqKey="Zago W" first="Wagner" last="Zago">Wagner Zago</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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